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The Ambient Light Multiple Myeloma Study
Systematic Light Exposure Effects on Circadian Rhythms Entrainment, Inflammation, Neutropenic Fever and Symptom Burden Among Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation
Who can join
Ages 21 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Multiple Myeloma diagnosis * Scheduled to undergo their first Autologous Stem Cell Transplant procedure. * 21years or older * Able to provide informed consent. * English-language proficient Exclusion Criteria: * Previous Autologous Stem Cell Transplant procedure * Pregnancy * Eye diseases which limit the ability of light to be processed * Secondary cancer diagnosis within the last 5 years * Severe sleep disorders * History of bipolar disorder or manic episodes * Severe psychological impairment * Previous use of light therapy * Active infection including COVID-19 infection
About the study
The aim of this multi-site randomized control trial will be is to assess the impact Systematic lighting on circadian rhythm entrainment, Inflammation, Neutropenic Fever and Symptom Burden among Multiple Myeloma Patients undergoing Autologous Stem Cell Transplantation. To achieve this aim, 200 multiple myeloma patients will receive one of two different light-treatments that are designed to promote circadian rhythm alignment. While receiving these light treatments, participants' sleep efficiency, urine melatonin levels, blood inflammatory cytokine levels and symptoms will be assessed over a 2-month period.
What is being tested
- Circadian Effective Lighting (device)
- Circadian Ineffective Lightning (CIL) (device)
Sponsor: Icahn School of Medicine at Mount Sinai · Participants: 200 · Started: Feb 13, 2023
Contact the study team
- Barbara Plitnick, BSN · Phone: 518 242-4603
- Mariana Figueiro, PhD · Phone: 518-366-9306
Official record on ClinicalTrials.gov — NCT05737732
Locations in the U.S.
| New York | Icahn Schoool of Medicine at Mount Sinai, New York Memorial Sloan Kettering Cancer Center, New York |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.