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International obServational sTudy on AiRway manaGement in operAting Room and Non-operaTing Room anaEsthesia

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* All adult (≥ 18 years old) patients undergoing advanced airway management for general anaesthesia in operating room (OR) or non-operating room anaesthesia (NORA).

Exclusion Criteria:

* Airway management during cardiopulmonary resuscitation.
* Critically ill patients undergoing intubation due to their underlying clinical condition

About the study

According to WHO, more than 230 million major surgical procedures are carried out under general anaesthesia each year worldwide. Despite important technological advances, airway management remains a major challenge in anaesthesiology. Data from large perspective studies on current incidence of major peri-intubation adverse events are lacking in the anaesthesia setting, especially on outcomes such as peri-intubation cardiovascular collapse, severe hypoxemia, and cardiac arrest. These events are more common in case of difficulties with airway management so that first pass intubation failure significantly increase the risks. Moreover, it has been documented that even transient hypotension during general anaesthesia, may have long-term consequences and may be associated with a worse outcome in patients undergoing non-cardiac surgery. The primary aim of the study is to assess the current incidence of major adverse events during advanced airway management for anaesthesia in patients undergoing elective or emergency surgery and in the setting of nonoperating room anesthesia. The secondary aim is to assess the current practice of airway management during anesthesia worldwide.

STARGATE Study will be a large international observational study recruiting all consecutive adult (≥ 18 years old) patients undergoing general anesthesia in operating room and outside operating room. Primary outcome will be a composite of cardiovascular collapse, cardiac arrest and severe hypoxemia.

What is being tested

• Advanced airway management (procedure)

Sponsor: University of Turin, Italy · Participants: 10,500 · Started: Jan 15, 2024

Contact the study team

• Vincenzo Russotto, MD · Phone: +393297893044
• Francesca Collino, MD · Phone: +393334320985

Official record on ClinicalTrials.gov — NCT05759299

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.