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OCT Vibrography for Biomechanical Properties of Tissues
RecruitingHealthy volunteers welcome
A Study to Test the Potential of OCT Vibrography for Measuring Biomechanical Properties of Tissues
Who can join
Ages 18 to 75 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Group 1: Inclusion criteria: • Subjects with healthy eyes (age 18 - 75, N = 50) Exclusion criteria: * Subjects with history of eye diseases, and previous eye surgeries. * Subjects with diabetes, glaucoma family history * Subjects allergic to anesthetic eyedrop, especially proparacaine * Subjects with severe allergy * Subjects who have difficulty biting * Subjects who have recurrent corneal erosion Group 2: Inclusion criteria: • Subjects with healthy skin (age 18 - 75, N = 10) Exclusion criteria: • Subjects with open cuts/sores on the skin, skin infection, or any contagious skin condition Group 3: Inclusion criteria: • Subjects with healthy gingiva (age 18 - 75, N = 10) Exclusion criteria: • Subjects with open cuts/sores on the gingiva, gingiva infection, or any contagious gingiva condition Group 4: Inclusion criteria: • Mild or moderate keratoconus subjects (age 18 - 40, N = 20) Exclusion criteria: • Subjects with K-max above 60 diopters (Pentacam imaging) are excluded
About the study
The overall goal of this study is to develop OCT Vibrography (aka OCT elastography) as a novel tool for measuring biomechanical properties of human tissues in vivo.
What is being tested
- Optical imaging of the tissues (device)
Sponsor: Massachusetts General Hospital · Participants: 90 · Started: Aug 19, 2023
Contact the study team
- Jing Zhang, PhD · Phone: 6173730127
- Seok-Hyun Yun, PhD · Phone: 6177688704
Official record on ClinicalTrials.gov — NCT05759780
Locations in the U.S.
| Massachusetts | Massachusetts General Hospital, Boston |
Conditions
From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.