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Oropharyngeal Candidiasis (OPC) and S-ECC

Association Between Early Candida Infection (Oral Thrush) and Severe Early Childhood Caries (S-ECC)

Who can join

9 Months – 15 Months · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Male or female individuals at the age of 9-15-month-old
* Must have at least one fully erupted tooth at baseline visit
* Parent/guardian willing and able to provide informed consent
* With or without a history of OPC (the study team will enroll 35 participants with and 35 participants without a history of OPC)

Exclusion Criteria:

* Presence of a systemic medical condition (e.g. Down syndrome etc.)
* Presence of an orofacial deformity
* Presence of dental caries
* Use of systemic antimicrobial therapy within 30 days of the baseline visit
* Presence of any condition which, in the opinion of the investigator, makes participation in the project not in the individual's best interest.

About the study

The overall objective of this study is to investigate the association of early Candida infection (known as oral thrush or oropharyngeal candidiasis, OPC) in children during the first year of life with the onset and severity of severe early childhood caries (S-ECC).

Sponsor: Temple University · Participants: 70 · Started: Sep 1, 2024

Contact the study team

• Yuan Liu, DDS, MS, PhD · Phone: 215-707-8029

Official record on ClinicalTrials.gov — NCT05761197

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.