Home › Postoperative Hemorrhage › NCT05774717
Tranexamic Acid in Rhinoplasty: Perioperative Bleeding, Edema and Ecchymosis
RecruitingPhase 1Healthy volunteers welcome
Who can join
Ages 18 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Adults at least 18 years of age who elect to undergo cosmetic or functional open primary rhinoplasty with osteotomies (repositioning the nasal bones) by Drs. Yang or Patel at VUMC. * No other facial plastics procedure nor sinus surgery performed simultaneously * Lack all the below Exclusion Criteria Exclusion Criteria: * Known allergy to TXA (tranexamic acid) * Intracranial bleeding * Known defective color vision * History of venous or arterial thromboembolism * Active thromboembolic disease * Severe renal impairment (diagnosis of chronic kidney disease) * History of coagulation disorder * Known thrombocytopenia (platelets \<150,000) * Current use of anticoagulant (blood thinner) * Uncontrolled DM (diabetes mellitus) preventing use of dexamethasone in the perioperative period * Cardiac arrhythmia * History of AMI (acute myocardial infarction), stroke, seizure, liver failure * Laboratory results showing platelets \<150,000, PT (prothrombin time) \>45, INR (international normalized ratio) \>1.2, seizure disorder
About the study
This study will be a prospective randomized study to evaluate the effect of tranexamic acid (TXA) use on intraoperative and postoperative outcomes among patients undergoing rhinoplasty by two Facial Plastic surgeons at Vanderbilt. Outcomes will include intra- and post-operative bleeding and postoperative bruising and swelling.
What is being tested
- Tranexamic acid (drug)
Sponsor: Vanderbilt University Medical Center · Participants: 60 · Started: Apr 1, 2023
Contact the study team
- Shiayin F Yang, MD · Phone: (615) 322-6180
- Jaclyn Lee, MD · Phone: (615) 322-6180
Official record on ClinicalTrials.gov — NCT05774717
Locations in the U.S.
| Tennessee | Vanderbilt University Medical Center, Nashville |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.