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The Role of Macrophage Activation in Lung Injury Following Ozone Exposure
Activated Macrophages and Ozone Toxicity II
Who can join
Ages 18 to 40 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Exclusion Criteria: * Cardiovascular disease * Respiratory disease * Recent (within 4 weeks) respiratory or COVID-19 symptoms * Diabetes * Pregnancy * HIV Infection * History of smoking within the past 5 years. * Orthopedic or rheumatologic conditions which would interfere with cycle use * Inability to produce a sputum plug at screening * Daily use of antioxidant supplements, excluding those in a multivitamin. These supplements include Vitamin C or E, selenium, beta-carotene, lycopene, lutein, zeaxanthin and ginkgo biloba. Supplements taken less frequently but at least once a week will be reviewed by the principal investigator for eligibility determination.
About the study
The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone. The exposure visits will be at least 2 weeks apart. Subjects will be asked to produce sputum through coughing after each exposure. The samples will be analyzed for macrophage activity.
What is being tested
- Clean Air (other)
- Ozone (other)
Sponsor: Rutgers, The State University of New Jersey · Participants: 120 · Started: Feb 7, 2023
Contact the study team
- Kathleen Black, PhD · Phone: 8484456049
- Adriana De Resende · Phone: 848-445-0178
Official record on ClinicalTrials.gov — NCT05794087
Locations in the U.S.
| New Jersey | Rutgers - EOHSI, Piscataway |
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.