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Ischemic Conditioning to Promote Microvascular Resiliency in Frail Individuals
Who can join
Ages 65 to 85 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Women and men ages 65-85 years of age Exclusion Criteria: * Myocardial infarction in last 6 months * morbid obesity (BMI \>40) * heart failure * uncontrolled hypertension * other condition that precludes high intensity exercise (ex, neurological disorder, acute systemic infection) * history of blood clots in the extremities * any condition in which compression of the arm or transient ischemia is contraindicated (e.g., wounds in the arm).
About the study
The goal of this clinical trial is to see how small blood vessels respond to the stress of high intensity exercise, and if a safe and simple intervention called ischemic conditioning can protect blood vessels from the stress of exercise.
Participants will come in for 3 study visits and get home-based ischemic conditioning. At Study Visit 1, participants will be assessed for their frailty and physical function. Afterwards, they will perform an exercise test. At Study Visit 2, patients will undergo 2 microvascular assessments, perform a high-intensity exercise, then undergo the same 2 microvascular assessments again. Participants will be given a handheld sphygmomanometer and a blood pressure cuff to take home. Depending on which group the participants get randomized into, participants will place the blood pressure cuff around their non-dominant upper arm and inflate to either a low or high pressure for 2 weeks at home. Participants will repeat the same steps in Study Visit 2 for Study Visit 3. In addition, participants will also be assessed for their frailty and physical function.
What is being tested
- Ischemic Conditioning (other)
Sponsor: Medical College of Wisconsin · Participants: 60 · Started: May 2, 2023
Contact the study team
- Jennifer Nguyen · Phone: 414-955-1917
- Matt Durand · Phone: 4149555619
Official record on ClinicalTrials.gov — NCT05808686
Locations in the U.S.
| Wisconsin | Froedtert Hospital, Wauwatosa |
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.