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Trial of Variable Dialysate Bicarbonate
Randomized, Controlled, Double-blind Trial of Lower Versus Higher Dialysate Bicarbonate in Hospitalized Maintenance Hemodialysis Patients
Who can join
Ages 18 to 120 · All sexes
Full eligibility criteria
Inclusion Criteria: * prevalent end-stage renal disease, on maintenance HD \> 90 days * age ≥ 18 years old * thrice weekly HD Exclusion Criteria: * hemoglobin \< 8.0 g/dL * pregnancy * any physical, mental or medical condition which limited the ability to provide written informed consent
About the study
QTc prolongation and premature ventricular contractions (PVCs) are common in hemodialysis (HD) patients and are associated with sudden cardiac death.
It is known that higher dialysate bicarbonate is associated with more QTc prolongation during HD sessions.
This study aims to assess the effects of lower (30 mEq/L) versus higher (35 mEq/L) dialysate bicarbonate in adult maintenance HD patients admitted to the hospital.
The investigators will randomly assign subjects to lower versus higher dialysate bicarbonate concentrations during their hospital stay for up to a maximum of six HD sessions or until their hospital discharge.
What is being tested
- Dialysate bicarbonate concentration (drug)
- Dialysate bicarbonate concentration - telemetry monitoring (device)
Sponsor: Brigham and Women's Hospital · Participants: 141 · Started: Aug 24, 2023
Contact the study team
- Katherine S Ravi, MD, MPH · Phone: (617) 732-6383
Official record on ClinicalTrials.gov — NCT05814146
Locations in the U.S.
| Massachusetts | Brigham and Women's Hospital, Boston |
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.