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Total Intravenous Anesthesia (TIVA)/Sevoflurane Initiated Intravenous Anesthesia (SIIVA) in Pediatric Patients
A Prospective Observational Study Evaluating Extubation Criteria in Children Less 10 Years of Age and Younger Undergoing Intravenous Anesthesia
Who can join
Up to age 9 · All sexes
Full eligibility criteria
Inclusion Criteria: * Pediatric patients \<10 years of age * Undergoing elective or emergency surgery with planned airway instrumentation with an endotracheal tube (ETT) * Patients having general anesthesia with a planned SIIVA or TIVA technique * Patients with an end tidal agent concentration of Sevoflurane\<0.1% at the time of emergence and extubation * following sevoflurane induction to place IV Exclusion Criteria: * History of home oxygen use or ventilator dependence * Patients with cyanotic congenital heart disease * Patients undergoing anesthesia for imaging procedures alone * Patients intended to be managed with supraglottic airway * Patients having an anesthesia time \< 30 minutes * Monitored Anesthesia Care (not general anesthesia) * Patients with contraindication to receiving Propofol (i.e. mitochondrial myopathy)
About the study
Because Propofol is the primary "anesthetic agent," and inhalational agents remain in trace quantities at the end of the procedure Sevoflurane initiated intravenous anesthesia (SIIVA) or not present at all Total intravenous anesthesia (TIVA) it is likely that different criteria may be predictive of extubation success in these patients compared to inhalational anesthesia.
What is being tested
- Total intravenous anesthesia (TIVA) (other)
- Sevoflurane initiated intravenous anesthesia (SIIVA) (other)
Sponsor: Wake Forest University Health Sciences · Participants: 600 · Started: Mar 28, 2023
Contact the study team
- Wes Templeton, MD · Phone: 336-716-4498
- Lynne Harris, BSN · Phone: 336-716-8791
Official record on ClinicalTrials.gov — NCT05837936
Locations in the U.S.
| North Carolina | Atrium Health Wake Forest Baptist, Winston-Salem |
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.