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Effect of Physical Activity Pattern on Cardiometabolic Health

Who can join

Ages 18 to 45 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* 18-45 yr old
* Body mass index (BMI) 18.5 - 34.9 kg/m2
* No acute, chronic or debilitating medical conditions (e.g. metabolic, cardiovascular, respiratory, neurological, cancers, etc.)
* Willing to adhere to the protocol requirements for the duration of the study

Exclusion Criteria:

* Currently smoking/vaping or 5 or more years of smoking/vaping
* Currently pregnant or breastfeeding
* History of drug or alcohol dependency
* History of psychiatric illness or disorder
* Any hospitalization due to COVID-19
* Inability to exercise for any reason
* Any known contraindication to exercise testing based on current ACSM guidelines

About the study

The goal of this study is to understand the interaction between the circadian system and physical activity.

Participants will:

* complete 2 inpatient stays * perform moderate exercise * be provided with identical meals * have frequent blood draws * provide urine and saliva samples

What is being tested

• Exercise intervention (behavioral)

Sponsor: Brigham and Women's Hospital · Participants: 26 · Started: Oct 11, 2024

Contact the study team

• Jingyi Qian, PhD · Phone: 6175257423
• Vy Nguyen, B.S. · Phone: 617-525-0662

Official record on ClinicalTrials.gov — NCT05838508

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.