Producing Increasingly Complex Themes Using Right-hemisphere Engagement (PICTURE) Implemented With Telemedicine
PICTURE IT: Producing Increasingly Complex Themes Using Right-hemisphere Engagement (PICTURE) Implemented With Telemedicine
Who can join
Ages 18 to 99 · All sexes
Full eligibility criteria
Inclusion Criteria: 1. Age 18 or older 2. Premorbid proficiency in English 3. Left hemisphere ischemic or hemorrhagic stroke confirmed by imaging, which occurred either 1-4 months or ≥ 6 months ago 4. Diagnosis of aphasia secondary to stroke as defined using the Western Aphasia Battery-Revised Aphasia Quotient \< 93.8. 5. Capable of giving informed consent or indicating another to provide informed consent Exclusion Criteria: 1. Prior history of neurologic disease affecting the brain (e.g., brain tumor, multiple sclerosis, traumatic brain injury) other than stroke 2. Prior history of severe psychiatric illness, developmental disorders or intellectual disability (e.g., PTSD, schizophrenia, obsessive-compulsive disorder, autism spectrum disorders) 3. Inability to follow the treatment procedure as indicated by appropriate (not necessarily accurate) engagement during 5 probes of each. 4. Uncorrected severe visual loss or hearing loss by self-report and medical records
About the study
The investigators propose a pilot crossover trial of 2 behavioral language treatments, with randomized order of treatments and blinded assessors, to determine if a therapy designed to stimulate right hemisphere functions (Producing Increasingly Complex Themes Using Right-hemisphere Engagement Implemented with Telemedicine - PICTURE IT; described below) is more effective in improving discourse than a published computer delivered lexical treatment (shown previously to improve naming) in subacute post-stroke aphasia.
What is being tested
- PICTURE-IT (behavioral)
- CoDeLT (behavioral)
Sponsor: Johns Hopkins University · Participants: 70 · Started: May 31, 2023
Contact the study team
- Argye E Hillis, MD · Phone: 410-614-2381
Official record on ClinicalTrials.gov — NCT05845047
Locations in the U.S.
| Maryland | Johns Hopkins School of Medicine, Baltimore |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.