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Effect of Opioid Cessation on Opioid-Induced Esophageal Dysfunction

Prospective Evaluation of the Effect of Opioid Cessation on Opioid-Induced Esophageal Dysfunction (OIED)

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

\- Patients enrolled in the Pain Rehabilitation Center for opioid cessation, with or without esophageal symptoms.

Exclusion Criteria:

* Inability to provide informed consent.
* Patients with previous gastroesophageal surgery or pneumatic dilation.
* Esophageal botulinum toxin injection within the prior 12 months.
* Esophageal stricture
* Achalasia types I and II
* Allergy to Lidocaine or other local anesthetics
* Subjects on anticoagulation
* Bilateral nasal obstruction
* Pregnancy or breast feeding

About the study

The purpose of this study is to evaluate the effect of opioid cessation on opioid-induced esophageal dysfunction (OIED).

What is being tested

• Opioid cessation (behavioral)
• No opioid cessation (other)

Sponsor: Mayo Clinic · Participants: 26 · Started: Sep 18, 2023

Contact the study team

• Mariah Robran · Phone: 507-266-3595

Official record on ClinicalTrials.gov — NCT05854303

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.