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A Study to Investigate the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle

Investigation of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle to Generate Higher Force Behaviors

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

\- Adult male and female patients undergoing lower extremity orthopedic surgery at the study institutions (St. Mary Hospital and Rochester Methodist Hospital within the Mayo Clinic Rochester hospital system).

Exclusion Criteria:

* Patients who refuse research participation.
* Patients who are pregnant.
* Patients with known pulmonary pathology (COPD, asthma requiring routine treatment).

About the study

The purpose of this study is to evaluate opioid dose effects on the ability of the diaphragm muscle to generate higher force behaviors.

What is being tested

• Fentanyl Injection (drug)

Sponsor: Mayo Clinic · Participants: 69 · Started: Jun 19, 2023

Contact the study team

Official record on ClinicalTrials.gov — NCT05856136

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.