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Exercise Response in Humans With Obesity
RecruitingObservational study
Who can join
Ages 20 to 45 · All sexes
Full eligibility criteria
Inclusion Criteria: * Obese men and women ≥ 20 and ≤ 45 years of age. Exclusion Criteria: * Diabetes or fasting plasma glucose \>126 mg/dL * Anemia (female subjects hemoglobin of \<11 g/dl and male subjects hemoglobin \<12 g/dl) * Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment) * Renal failure (serum creatinine \> 1.5mg/dl) * Chronic active liver disease defined as aspartate aminotransferase (AST)\>144 IU/L or alanine transaminase (ALT) \>165 IU/L) * Oral warfarin group medications or history of blood clotting disorders. * Smoking * Pregnancy or breastfeeding * Alcohol consumption greater than 2 glasses/day or other substance abuse * Untreated or uncontrolled hypothyroidism * Debilitating chronic disease (at the discretion of the investigators)
About the study
This study is being done to understand how chronic inflammation affects muscle function and responses to exercise.
What is being tested
- Treadmill Test (diagnostic test)
- Strength Test (diagnostic test)
- Dual-Energy X-Ray Absorptiometry (diagnostic test)
- Muscle Biopsy (procedure)
- Fat Biopsy (procedure)
- Resting Energy Expenditure (diagnostic test)
Sponsor: Mayo Clinic · Participants: 120 · Started: Sep 22, 2023
Contact the study team
- Rachel Osland · Phone: 507-255-8112
Official record on ClinicalTrials.gov — NCT05857150
Locations in the U.S.
| Minnesota | Mayo Clinic in Rochester, Rochester |
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.