Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Enrollment in the CAPTIVA trial: nondisabling symptomatic ischemic infarct stroke within 30 days secondary to 70-99% stenosis of the intracranial ICA, MCA, BA or VA * Ability to obtain baseline study MRI within 14 days of CAPTIVA enrollmen Exclusion Criteria: * Unable or unwilling to undergo MRI, including pacemaker or other MRI contraindications per American College of Radiology guidelines62 * Gadolinium contrast allergy or acute or chronic kidney disease with eGFR\<30 ml/min/1.73m2
About the study
CAPTIVA-MRI is an observational multimodal MR imaging study that is ancillary to the CAPTIVA trial \[a 3-arm, double-blind Phase III trial conducted at approximately 115 StrokeNet sites randomizing patients with stroke attributed to 70-99% intracranial atherosclerotic stenosis (ICAS) to aspirin plus ticagrelor, clopidogrel, or rivaroxaban.\] The primary goal of this ancillary study is to determine if MRI biomarkers can potentially identify ICAS patients who fail best medical management. The CAPTIVA-MRI study leverages the CAPTIVA trial design and implementation to capture information that will inform and facilitate the next generation of ICAS trials and the management of patients with ICAS.
What is being tested
- MRI (other)
Sponsor: Yale University · Participants: 300 · Started: Jun 24, 2024
Contact the study team
- Ka-Ho Wong · Phone: 801-585-7575
Official record on ClinicalTrials.gov — NCT05907629
Locations in the U.S.
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.