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MRI Neurofeedback and Brain Circuits Related to Motivation in Healthy Participants
RecruitingHealthy volunteers welcome
Bridging Scales to Understand Endogenous Neuromodulation and Its Regulation
Who can join
Ages 18 to 45 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Age between 18 and 45 years * Right-handed * In good general health Exclusion Criteria: * Current or diagnosis within past six months of an DSM-V Axis I or Axis II disorder (self-reported) * CES-D score of 20 or higher (indicating significant current depression symptoms) * Current or past six month use of prescription medications indicated for psychiatric conditions (e.g.,depression, anxiety) * Current serious medical illness (self-reported) * Head injury resulting in loss of consciousness * For participants age \> 59 years, a total scaled score \< 8 on the Dementia Rating Scale-2. * A clinically-defined neurological disorder including, but not limited to: * Any condition likely to be associated with increased intracranial pressure * Space occupying brain lesion * History of stroke * Transient ischemic attack within two years * Cerebral aneurysm * Dementia * Mini Mental Status Exam (MMSE) score of \<24 * Parkinson's disease * Huntington's disease * Multiple sclerosis * Presence of cochlear implants or other implanted electronic devices or non-removable metal (e.g., non-removable piercing, IUD) * History of an eye injury involving metal. Participants who worked with metal may be allowed to participate on a case-by-case basis with prior written approval from BIAC. * Claustrophobia or unwillingness to tolerate the confinement associated with being in the MRI scanner. * Weight of more than 250 pounds
About the study
The purpose of this research study is to understand how healthy individuals self-regulate motivation by observing brain activity using magnetic resonance imaging (MRI).
What is being tested
- Ventral tegmental area of dopaminergic midbrain (VTA) fMRI neurofeedback (behavioral)
Sponsor: Duke University · Participants: 190 · Started: Jul 30, 2023
Contact the study team
- Alannah Rivera-Cancel, BA · Phone: 919-385-0836
- R. Alison Adock, MD, PhD · Phone: 919-681-4601
Official record on ClinicalTrials.gov — NCT05929898
Locations in the U.S.
| North Carolina | Center for Cognitive Neuroscience, Durham |
From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.