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Effects of Novel E-cigarette Constituents on Adults TCORS 3.0

Examining Appeal and Addiction Potential of Novel E-cigarette Constituents Among Adults

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* 18 years or older
* Able to read and write
* Some current e-cigarette use
* Urine cotinine ≥200ng/ml
* Willing to abstain from tobacco/nicotine use 2 hours prior to sessions

Exclusion Criteria:

* Current use of non-prescription substances besides nicotine, marijuana, alcohol
* Any significant current medical or psychiatric condition
* Known hypersensitivity to propylene glycol
* Pregnant or lactating females
* Uncontrolled asthma
* Nut/e-liquid flavorant allergy
* Current marijuana (tetrahydrocannabinol) vaping + E-cigarette or vaping use Associated Lung Injury (EVALI) symptoms
* Dislike of menthol flavor

About the study

This study is an examination of the influence of cooling components of WS-3, WS-23, and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults.

What is being tested

• E-liquid coolant (No WS-3) for non-menthol (1) (other)
• E-liquid coolant (No WS-3) for low (0.1%) menthol (1) (other)
• E-liquid coolant (No WS-3) for high (2.0%) menthol (1) (other)
• E-liquid coolant (Low [0.1%] WS-3) for non-menthol (2) (other)
• E-liquid coolant (Low [0.1%] WS-3) for low (0.1%) menthol (2) (other)
• E-liquid coolant (Low [0.1%] WS-3) for high (2.0%) menthol (2) (other)

Sponsor: Yale University · Participants: 66 · Started: Jun 20, 2025

Contact the study team

• Danielle Davis, PhD · Phone: 203-974-7607

Official record on ClinicalTrials.gov — NCT05932745

Locations in the U.S.

Conditions

• Quitting Smoking (Tobacco Use Disorder)
• Vaping

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.