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Examining the Role of Female Endogenous Sex Hormones in Eccentric Exercise
Who can join
Ages 18 to 35 · Women · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * 18-35 years of age * BMI of 18.5-29.9 as a BMI below or above these cut points results in highly varied menstrual cycle lengths \[15\] * Not taking contraception or other types of medication that could influence reproductive status * Regular menstruation * Non-pregnant * Medically free from chronic diseases * Novel to downhill running * Weight greater than or equal to 110 lbs * Not taking exogenous hormones * Not suffering from known gynecological disease (i.e., PCOS, endometriosis, etc.) that may influence menstrual cycle regularity Exclusion Criteria: * Amenorrhea or oligomenorrhea * Perimenopausal or menopausal * Recreational or professional trail or downhill runner * On a form of contraception * Cardiac disability * Pacemaker * Arterial disease * Uncontrolled hemorrhage * Blood clots * Pregnant or trying to become pregnant * Cancerous lesions * Sensory or mental impairment * Unstable fractures * Weight less than 110 lbs * Suffering from gynecological disease (i.e., PCOS, endometriosis, etc.) that may influence menstrual cycle regularity * Taking exogenous hormones
About the study
The fluctuating concentrations of female sex hormones, namely estrogen and progesterone may have an effect on the ability of the tissue to withstand challenging exercise conditions, such as eccentric exercise. These sex hormones have also been purported to influence the perceived difficulty of exercise. This study aims to uncover how the different estrogen and progesterone concentrations present throughout the menstrual cycle effect perceived readiness to perform, perceptions of difficulty, and different recovery metrics.
What is being tested
- Eccentric leg extension (behavioral)
Sponsor: University of Southern California · Participants: 30 · Started: Mar 7, 2025
Contact the study team
- Todd Schroeder, PhD · Phone: 3234422180
Official record on ClinicalTrials.gov — NCT05934708
Locations in the U.S.
| California | Clinical Exercise Research Center, Los Angeles |
From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.