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Oxidative Stress in Microvascular Dysfunction Following Gestational Diabetes
RecruitingEarly phase 1Healthy volunteers welcome
Role of Oxidative Stress in Microvascular Dysfunction Following Gestational Diabetes
Who can join
Ages 18 to 50 · Women · Healthy volunteers welcome
Full eligibility criteria
INCLUSION CRITERIA: * female sex * 18 -50 years old * pregnancy history within 5 years of the study visit * had gestational diabetes diagnosed by their obstetrician and confirmed according to the American College of Obstetricians and Gynecologists criteria for gestational diabetes * or without a history of gestational diabetes EXCLUSION CRITERIA: * skin diseases * current tobacco/e-cigarette use * diagnosed or suspected hepatic or metabolic disease including diabetes * statin or other cholesterol-lowering medication * current antihypertensive medication * history of preeclampsia or gestational hypertension * current pregnancy * body mass index \<18.5 kg/m2 * allergy to materials used during the experiment.(e.g. latex), known allergies to study drugs.
About the study
The purpose of this investigation is to examine the role of oxidative stress in aberrant microvascular function in otherwise healthy women with a history of GDM.
What is being tested
- Acetylcholine (drug)
- insulin aspart (drug)
Sponsor: Anna Stanhewicz, PhD · Participants: 28 · Started: Jul 1, 2023
Contact the study team
- Anna Reid-Stanhewicz, PHD · Phone: 319-467-1732
Official record on ClinicalTrials.gov — NCT05946785
Locations in the U.S.
| Iowa | University of Iowa, Iowa City |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.