Home › NCT05954832

A Study of Changes in Heart Function and Blood Flow in People Receiving Anesthesia

Changes in Loading Conditions on Induction of General Anesthesia: Mechanisms of Post-Induction Hypotension (PIH)

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Adult patients ≥ 18 years of age requiring general anesthesia for surgery
* Intubation required for anesthetic management / surgery
* Anticipated prep time before incision of 20 minutes
* Baseline MAP \>70mmHg

Exclusion Criteria:

* History of coronary artery disease
* History of cardiac disease (e.g., HTN, arrythmias, valvular and structural abnormalities)
* History of peripheral artery occlusive disease
* Beta-blocker use
* Anti-hypertensive medication use
* Patients with epidural, spinal, paravertebral, serratus blocks preoperatively
* Patients requiring rapid sequence induction (where intubation occurs concurrently with induction)
* Emergency surgery

About the study

The purpose of this study is to understand changes in heart function (how the heart pumps blood) and blood flow in people who receive general anesthesia during surgery. The researchers are particularly interested in the heart function and blood flow changes in people who experience low blood pressure (hypotension) after receiving anesthesia.

What is being tested

• Echocardiography (diagnostic test)

Sponsor: Memorial Sloan Kettering Cancer Center · Participants: 250 · Started: Jul 13, 2023

Contact the study team

• Anahita Dabo-Trubelja, MD · Phone: 212-639-3279
• Gregory Fischer, MD · Phone: 212-639-2581

Official record on ClinicalTrials.gov — NCT05954832

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.