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Operative vs Non-operative Management of Posterior-medial Meniscal Root Tears: A Randomized Multicenter Trial (RCT)
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * MRI-verified isolated tibial medial meniscus root tear * Subject must be 18 years of age or older Exclusion Criteria: * Concurrent ligamentous knee pathology requiring surgical intervention (i.e. anterior cruciate ligament tear, posterior cruciate ligament tear, posterolateral corner injury, high-grade medial collateral ligament tear), * Preoperative Kellgren-Lawrence grade of 3 or 4 * Inability to complete outcome questionnaires or comply with required postoperative imaging or MRI requirements, or medical contraindications to surgery or physical therapy. * There will be no exclusion criteria regarding body mass index (BMI) or mechanical alignment, however subjects will be stratified in groups for further analysis (BMI less and over 35 and varus alignment below and over 3º of varus). * Pregnancy * Subjects \< 18 years of age
About the study
The purpose of this study is to determine differences in pain, functional patient reported outcomes, and objective imaging parameters following non-operative and meniscus root repair treatment. Furthermore, the long-term goal of this research proposal is to understand the natural history of meniscal root tears and their subsequent repair, in order to better determine risk factors for inferior outcomes and progression to osteoarthritis (OA).
What is being tested
- Non-Operative Pain Management (other)
- Operative treatment arm will undergo transtibial medial meniscus root repair within 3 weeks of enrollment (procedure)
Sponsor: Rush University Medical Center · Participants: 140 · Started: Apr 20, 2022
Contact the study team
- Carla M. Edwards, PhD · Phone: 312-563-5735
- Jorge Chahla, MD · Phone: (312) 432-2818
Official record on ClinicalTrials.gov — NCT05985772
Locations in the U.S.
| Illinois | Rush University Medical Center, Chicago |
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.