Home › Bulimia Nervosa › NCT05995496
Changes in Inhibition and Valuation After Eating
Dynamic Neural Computations Underlying Cognitive Control in Bulimia Nervosa
Who can join
Ages 18 to 45 · Women · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Female * Aged 18 to 45 years * Current BMI greater than or equal to 18.5kg/m2 but under 30kg/m2 * Right-handed * English-speaking Additional Inclusion Criteria for Women with Bulimia Nervosa: * Meet DSM-5 criteria for bulimia nervosa Exclusion Criteria: * Medical instability * Ongoing medical treatment, medical condition, or psychiatric disorder that may interfere with study variables or participation * Shift work * Pregnancy, planned pregnancy, or lactation during the study period * Allergy to any of the ingredients in or unwillingness to consume the standardized meal or unwillingness to drink water during the fasting period * Any contraindication for fMRI
About the study
An impaired ability to exert control has been implicated in bulimia nervosa (BN), but this impairment may not represent a stable trait or be the most effective focus for treatment. This project aims to understand how predictions and value-based decisions about control may be abnormally influenced by eating in individuals with BN, thereby maintaining cycles of binge eating, purging, and restriction.
What is being tested
- Fasting state (other)
- Fed state (other)
- Magnetic Resonance Imaging (other)
Sponsor: Icahn School of Medicine at Mount Sinai · Participants: 150 · Started: Dec 12, 2023
Contact the study team
- Riley Macks, B.A. · Phone: (212) 824-9545
- Riley Macks · Phone: (212) 824-9545
Official record on ClinicalTrials.gov — NCT05995496
Locations in the U.S.
| New York | Center of Excellence in Eating and Weight Disorders at the Icahn School of Medicine at Mount Sinai, New York |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.