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Peripheral Nerve Stimulation of Genicular Nerves Versus Conventional Therapy With Intra-articular Steroid Injection for Chronic Knee Pain: A Prospective, Randomized Pilot Study

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Patients diagnosed with chronic knee pain (baseline pain score \>=4), seen at Pain Management Center at MD Anderson Cancer Center; if patient has bilateral knee pain, the side with the more severe knee pain will be treated first and counted towards the primary and secondary endpoints
* Patients between ages 18-85 years old
* Patient signed informed consent

Exclusion Criteria:

* Patients with cognitive dysfunction or without capacity to consent
* Patient with recent history (\<6 months) of drug or alcohol abuse
* Patients with open skin lesion or undergoing antibiotic therapy for local for systemic infection
* Patients with allergies to local anesthesia, steroids, or adhesives
* Patients who are on opioids for reasons other than knee pain

About the study

To compare the effects of the following types of therapy on knee range of motion when given to patients with chronic knee pain:

* A standard steroid injection * Peripheral nerve stimulation (PNS) therapy in combination with a standard steroid injection * PNS therapy in combination with a placebo injection

Steroid injections are given directly into the knee joints and are considered to be the standard therapy for chronic knee pain. In this study, the injection will be made of the steroid drugs triamcinolone and bupivacaine.

What is being tested

• PNS therapy (other)
• Triamcinolone (drug)
• Bupivacaine (drug)
• Placebo (other)

Sponsor: M.D. Anderson Cancer Center · Participants: 45 · Started: Aug 10, 2023

Contact the study team

• Saba Javed, MD · Phone: (713) 792-9530

Official record on ClinicalTrials.gov — NCT06004882

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.