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Midwest Birth Outcomes and Indigenous American Pregnancy

Midwest Birth Outcomes and American Indian Pregnancy: Associations With Historical Trauma and Psychosocial Stress

Who can join

Ages 18 and older · Women · Healthy volunteers welcome

Inclusion Criteria:

* At least 18 years old
* Less than 26 weeks
* Healthy single baby pregnancy
* Indigenous American

Exclusion Criteria:

* Assistive reproductive technology (in-vitro fertilization)
* Have a history of cardiac and endocrine disease

About the study

Indigenous American pregnancies in the Midwest have disproportionally high rates of adverse outcomes, however little research has been done on how historical trauma and stress may impact these adverse outcomes. This project gathers data from pregnant Indigenous American women on their experiences with historical trauma, stress, and birth outcomes, as well as physiological data of how they respond to stress, in order to better understand the associations between these factors and the biological mechanisms underlying them. Understanding the mechanisms by which both historical and proximal stress "get under the skin" and influence pregnancy health and perinatal outcomes, will afford new targets of intervention to help reduce these IA health disparities.

Sponsor: Sanford Health · Participants: 80 · Started: Oct 31, 2023

Contact the study team

• Grace Biermann, MPH · Phone: 6053126457

Official record on ClinicalTrials.gov — NCT06008561

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.