Blood Flow Regulation and Neuromuscular Function Post-Stroke
Who can join
Ages 18 to 85 · All sexes
Full eligibility criteria
Inclusion Criteria: * Be between 18-85 years of age * Able to give informed consent * ≥6 months post diagnosis of unilateral cortical or sub-cortical stroke * English speaking Exclusion Criteria: * History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (e.g. wounds in the leg) * Chronic pain syndrome * Low back or hip pain that interferes with lower extremity motor testing * History of head trauma * Comorbid neurological disorder * Peripheral vascular disease * Myocardial infarction in the previous year * Inability to follow 2 step commands * Condition where fatiguing contractions or resisted leg contractions are contraindicated * Resting SBP ≥160 mmHg or DBP ≥ 110 mmHg * Pregnancy or breastfeeding.
About the study
The muscles of stroke survivors can fatigue faster compared to muscles in people who have not had a stroke, which can limit how long a person with stroke can perform tasks such as walking. This study will examine how blood flow is regulated to the exercising leg muscle post-stroke, because if the muscle does not receive enough blood flow it will become fatigued. Finally, the investigators will use a safe and simple non-invasive intervention called ischemic conditioning, which has known effects to improve blood flow to exercising muscle and determine the effects on muscle fatigue.
What is being tested
- Ischemic Conditioning (procedure)
Sponsor: Medical College of Wisconsin · Participants: 40 · Started: Jan 11, 2024
Contact the study team
- Matthew Durand, Ph.D. · Phone: 4149555619
Official record on ClinicalTrials.gov — NCT06027294
Locations in the U.S.
| Wisconsin | Marquette University, Milwaukee Medical College of Wisconsin, Milwaukee |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.