Measuring Environmental Tobacco and Cannabis: Pollutants and Exposures

Inclusion Criteria:

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Adult nonsmokers, aged 21-50, who:

* Are healthy on the basis of medical history
* Have systolic blood pressure \<150
* Have diastolic blood pressure \<100
* Have BMI between 18.1 and 34.9
* Able to perform moderate exercise,
* Are not exposed to tobacco or cannabis SHS in their daily lives. (Nonsmoking status and low SHS exposure are determined by self-report on the screening questionnaire, salivary cotinine \< 10 ng/ml and THC \< 50 ng/m and exhaled CO2 below 4 ppm)

Exclusion Criteria:

* Current use of cannabis products, including CBD and edible THC products
* Regular exposure to secondhand tobacco or cannabis smoke
* Positive SARS-CoV-2 antibody test
* Age 18 \< or \> 50
* Physician diagnosis of asthma, heart disease, hypertension, thyroid disease, diabetes, renal or liver impairment or glaucoma.
* Unstable psychiatric condition (such as current major depression, history of schizophrenia or bipolar disorder) or current use of more than two psychiatric medications
* Systolic blood pressure \> 150
* Diastolic blood pressure \> 100
* Pregnancy or breastfeeding (by urine hCG and/or history)
* Alcohol or illicit drug dependence within the past 5 years
* BMI \> 35 and \< 18
* Current illicit drug use (by history or urine test)
* More than 1 pack year smoking history
* Ever a daily marijuana smoker
* Smoked anything within the last 2 months
* Occupational exposure to smoke, dusts OR fumes
* Concurrent participation in another clinical trial
* Unable to communicate in English
* No social security number