Home › Phantom Limb › NCT06045936
A Study of Contralateral Limb Block
RecruitingPhase 4
Sciatic Block in Contralateral Limb for Treatment of Refractory Phantom and Residual Limb Pain; a Double-Blind Randomized Controlled Trial
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Lower extremity amputation performed more than 12 months before study enrollment * PLP/RLP in affected amputated limb \> 4 on NRS26 * Pain duration of more than 6 months despite a trial of conservative therapies for at least 2 months, including oral medications, topical medicines, physical therapy, and physical modalities (i.e., heat, cold, transcutaneous electrical nerve stimulation, phonophoresis) * Willingness to undergo image guided diagnostic nerve block Exclusion Criteria: * Refusal / inability to participate or provide consent * Contraindications to diagnostic nerve block * Non-neurogenic source of PLP/RLP * Current opioid use \> 50 morphine milligram equivalents per day * Any interventional pain treatment in the residual limb within the last 30 days * Severe uncontrolled medical condition (i.e., hypertensive crisis, decompensated hypothyroidism) * Use of investigational pain drug within past 30 days or other concurrent clinical trial enrollment
About the study
This research is being done to determine if an anesthetic like Lidocaine, may be effective when injected around the sciatic nerve of the intact limb in patients with limb loss pain on the contralateral side.
What is being tested
- Lidocaine (drug)
- Placebo (drug)
Sponsor: Mayo Clinic · Participants: 20 · Started: Jun 18, 2024
Contact the study team
Official record on ClinicalTrials.gov — NCT06045936
Locations in the U.S.
| Minnesota | Mayo Clinic Health System - Mankato, Mankato |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.