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Non-Invasive Ventilation Versus Neurally-Adjusted Ventilatory Assistance (NAVA) for the Treatment of Bronchiolitis

Comparison of Conventional Non-Invasive Ventilation and Neurally-Adjusted Ventilatory Assistance (NAVA) Non-Invasive Ventilation for the Treatment of Bronchiolitis

Who can join

Ages 0 to 2 · All sexes

Inclusion Criteria:

* Patients under the age of two years old with a diagnosis of bronchiolitis presenting to the pediatric ICU
* Patient's provider believes there is equipoise between the use of NAVA or conventional non-invasive ventilation for the patient

Exclusion Criteria:

* Patients unable to utilize a nasogastric tube
* Patients with a diagnosis of chronic lung disease, cyanotic heart lesions, or congestive heart failure
* Patients with hypotonia
* Patients likely to require imminent intubation: \>0.60 Fraction of Inspired Oxygen (FiO2); Carbon Dioxide (CO2) \> 60, frequent apneas, clinician determines patient unlikely to tolerate non-invasive modality)
* Patients with hemodynamic instability, defined as the need for vasoactive medication

About the study

This project aims to answer whether the use of a Neurally-Adjusted Ventilatory Assistance mode for non-invasive ventilation in pediatric patients with bronchiolitis results in improved comfort and reduced escalations in therapy (including intubation) when compared to using a standard mode of non-invasive ventilation. Neurally-Adjusted Ventilatory Assistance (NAVA) has been shown to result in greater synchrony then the standard mode of non-invasive ventilation. The study team hypothesizes that this improved synchrony can result in important clinical improvements when NAVA is used to treat children with bronchiolitis.

What is being tested

• Standard Non-Invasive Mechanical Servo Ventilation (device)
• Neurally-Adjusted Ventilatory Assistance (NAVA) Non-Invasive Mechanical Servo Ventilation (device)

Sponsor: Montefiore Medical Center · Participants: 130 · Started: Dec 18, 2023

Contact the study team

• Jacqueline Weingarten, MD · Phone: 2017459825

Official record on ClinicalTrials.gov — NCT06053684

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.