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Somatic Mosaicism in Twins Discordant for Childhood Cancer

Somatic Mosaicism in Twins Discordant for Childhood Cancer: a Pilot Study

Who can join

Up to age 18 · All sexes

Inclusion Criteria:

* Newly diagnosed patient with CNS tumor or have recurrent disease and enrolled on APEC14B1.
* Patient must have same sex twin. Note: (history of) treatment on a COG therapeutic trial is not required.
* Patients must be diagnosed at \< 19 years of age at the time of diagnosis.
* A family is eligible to participate if the twin with the CNS tumor is deceased but has a blood sample banked through APEC14B1.
* All patients and/or their parents or legal guardians must provide informed consent. Assent will be obtained for participants between the ages of 8-17 years.
* All institutional, FDA, and NCI requirements for human studies must be met.

About the study

Somatic mosaicism in cancer associated genes is one potential explanation for discordance in childhood cancer that has not been fully explored to date. This pilot study will focus on twins with central nervous system (CNS) tumors who are identified through the Children's Oncology Group's Project: EveryChild (PEC) registry or volunteer.

What is being tested

• Biospecimen collection (other)
• Questionnaire Administration (other)

Sponsor: Children's Oncology Group · Participants: 50 · Started: Jun 3, 2024

Contact the study team

• Jenny Poynter, PhD · Phone: (612) 625-4232

Official record on ClinicalTrials.gov — NCT06054295

Locations in the U.S.

Conditions

• Brain and Spinal Cord Tumors

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.