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Biomarkers of Reaction To HIIT Exercise
What Makes a Responder, a Responder? Biomarkers to Help Identify Responders and Resistors to High-intensity Interval Training for Lower Extremity Chronic Stroke
Who can join
Ages 18 to 89 · All sexes
Full eligibility criteria
Inclusion Criteria: * chronic left or right subcortical stroke as defined by 6 months or more after a cardiovascular accident * lower extremity motor impairment due to stroke that causes a walking speed of less than 0.6 m/s during a 10m walk * Veteran status Exclusion Criteria: * MRI contraindications, including implanted cardiac pacemakers and severe claustrophobia * any neurodegenerative condition other than stroke that may lead to lower extremity impairment * a visual or auditory impairment that may hinder study procedures * any medical condition that would preclude participation in a physical exercise intervention program
About the study
Stroke survivors with lower limb disability can improve their walking speed with high-intensity interval training (HIIT) rehabilitation therapy. However, some individuals may not respond to HIIT even when fully adherent to the program. To address this, the investigators propose to build a predictive model that identifies if a Veteran with chronic subcortical stroke will improve their walking speed with HIIT by incorporating blood lactate as an early predictor of exercise response, and inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and regional cerebral blood flow (CBF) as predictors of the brain's potential to respond, while also taking into consideration other factors such as comorbidities, demographics, and fitness levels.
What is being tested
- High Intensity Interval Training (HIIT) (other)
Sponsor: VA Office of Research and Development · Participants: 55 · Started: Jan 1, 2024
Contact the study team
- Lisa C Krishnamurthy, PhD · Phone: (404) 321-6111
Official record on ClinicalTrials.gov — NCT06059872
Locations in the U.S.
| Georgia | Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur |
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.