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Addressing Genomic Disparities in Cancer Survivors

Who can join

Ages 18 to 80 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* 18-80 years of age
* Self-identify as Black or African American
* At least 6-months post diagnosis with any of the following cancers: breast, ovarian, uterine, prostate, colorectal, pancreatic
* Have not had genetic testing for hereditary cancer
* Have received care at one of the participating sites in the prior five years
* Meet National Comprehensive Cancer Network criteria for germline GT
* Able to read and speak in English
* Capable of providing informed consent
* Have internet access (via smartphone, tablet or computer)
* Comfortable using a computer or mobile phone independently to access information

Exclusion Criteria:

* Do not speak English
* Unable to access the Internet
* Have previously undergone germline genetic testing for hereditary cancer risk or previously had genetic counseling (GC) and declined genetic testing (GT)
* Are unable to provide informed consent

About the study

The goal of this observational study is to increase genetic education and genetic testing for hereditary cancer risk among Black cancer survivors. The study will:

1. Test the effectiveness of a chatbot intervention (also called relational agent, or RA) vs. enhanced usual care (EUC) on engagement in genetic education and requests for genetic testing. 2. Evaluate the impact of the chatbot vs. EUC on the process that participants use to make decisions and evaluate effects on well-being (also called psychosocial outcomes). 3. Explore the ways (methods) that influence how participants experience the intervention. 4. Explore the feasibility of incorporating a Family Sharing Portal (FSP) for participants who receive a positive test result, to facilitate family communication of these test results and genetic testing of first-degree biological relatives after they have received genetic education by the RA.

The main questions this study aims to answer are which group - the chatbot (RA) group or the EUC group - is more likely to request genetic testing and which group is more likely to get (engage with) genetic education.

Participants will be randomly assigned to either the chatbot (RA) group or EUC group. This means each participant has an equal chance of being placed in either group, just like flipping a coin. Each group will receive genetic education and have an opportunity to request genetic testing. Researchers will compare the chatbot (RA) group and the EUC group to see which may request more GT (genetic testing) and which group engages more with genetic education.

What is being tested

• Relational agent (RA) / Chatbot (behavioral)
• Enhanced Usual Care (EUC) (behavioral)

Sponsor: Rutgers, The State University of New Jersey · Participants: 428 · Started: Jul 31, 2024

Contact the study team

• Erin Speiser, PhD, MA · Phone: 732-675-1668

Official record on ClinicalTrials.gov — NCT06073626

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.