Home › Smoking and Youth › NCT06077240
Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction
Evaluating The Effects Of E-cigarettes Versus Oral Nicotine Pouches and Product Constituents (Menthol Flavor, Nicotine Concentration) On Adult Cigarette Smoking and Addiction
Who can join
Ages 21 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * 21+ years old * English literate * Currently smoking cigarettes, biochemically confirmed Exclusion Criteria: * Currently using smoking cessation pharmacotherapies (NRT, bupropion, varenicline) * Currently pregnant or breastfeeding * Significant current medical or psychiatric condition * Known hypersensitivity to propylene glycol
About the study
The study will recruit an anticipated 256 adults who currently smoke cigarettes and report a willingness to try switching to alternative, non-combustible products. Participants will be randomized to receive either e-cigarettes or nicotine pouches for a duration of 4 weeks and to 1 of 4 possible regulatory scenarios within products where flavor availability is either menthol and tobacco/unflavored available or tobacco/unflavored only available, and nicotine concentration is either higher (5% e-cig, 6mg pouch) or lower (2.4% e-cig, 3mg pouch). Participants will return for bi-weekly research visits (in person or remote videocall) to complete measures for study aims. Participants will complete a final follow-up at Week 6 to assess maintenance of cigarette reduction and willingness to continue using products once they are no longer provided. The investigators expect to observe which products and constituents lead to greater smoking reduction.
What is being tested
- E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors (behavioral)
- E-cigarette with 2.4% Nicotine with Tobacco Flavor Only (behavioral)
- E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors (behavioral)
- E-cigarette with 5% Nicotine with Tobacco Flavor Only (behavioral)
- Tobacco Pouches with 3mg Nicotine with Menthol and Tobacco Flavors (behavioral)
- Tobacco Pouches with 3mg Nicotine with Tobacco Flavor Only (behavioral)
Sponsor: Yale University · Participants: 256 · Started: Aug 20, 2024
Contact the study team
- Lisa M. Fucito, PhD · Phone: 203-200-1470
- Krysten W Bold, PhD · Phone: 203-974-7603
Official record on ClinicalTrials.gov — NCT06077240
Locations in the U.S.
| Connecticut | Yale University, New Haven |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.