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Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool

Who can join

Ages 18 to 80 · All sexes

Inclusion Criteria:

* Age 18-80 years
* Listed for liver transplantation at MGH
* Calculated MELD-Na score \<= 25
* Able to consent

Exclusion Criteria:

* Status 1a
* Cardiac or pulmonary disease
* Prior liver transplant
* Requiring pressors at the time of liver offer
* MELD\<15 and asymptomatic from liver disease

About the study

The goal of this clinical trial is to assess the ability of Normothermic Machine Perfusion (NMP) to resuscitate moderately steatotic livers for transplantation in patients. This will be a single-site clinical trial placing donor livers with 30-60% macrosteatosis on NMP, and then transplanting those that meet commonly accepted viability criteria. The results of this study could lead to a trial extending NMP transplantation to severely steatotic livers, further expanding the donor organ pool.

What is being tested

• Normothermic machine perfusion (NMP) of steatotic liver (device)

Sponsor: Massachusetts General Hospital · Participants: 200 · Started: Feb 28, 2024

Contact the study team

• Heidi Yeh, MD · Phone: 617-643-4533

Official record on ClinicalTrials.gov — NCT06088758

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 3, 2026. Each study sets its own eligibility; the study team decides who can join.