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Genetic Information Assistant in Telegenetics

A Prospective, Randomized Trial to Compare Telegenetics to Counseling Via a Novel Genetic Information Assistant in High-risk Cancer Patients.

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* At high risk for having a genetic pathogenic variant as assessed by a GC or physician according to the NCCN guidelines
* Provision of signed and dated informed consent form.
* Stated willingness to comply with all study procedures and availability for the duration of the study.
* Male or female, aged 18 and over.
* Subjects must have a smartphone with access to cellular and/or internet service or a computer with internet service.
* Subjects must have technological competency/proficiency to use their Smartphone and/or computer in conjunction with the communication aid GIA.

Exclusion Criteria:

* Cannot communicate in English or Spanish.
* Subjects must not have completed panel-based cancer genetic testing in the past.

About the study

The goal of this clinical trial is to learn about different ways cancer genetic screening can be provided to rural communities in participants at high risk for certain cancers. The main question it aims to answer is:

• Does receiving pre-genetic test education with a chat bot or genetic counselor affect if the participant decides to get genetic testing?

Participants will:

* have a pre-test genetic counselling session with a genetic counselor or the GIA chatbot * answer questions about their cancer genetic knowledge and how they are doing * provide a saliva sample for genetic testing to test for cancer gene mutations * have their genetic testing results provided to them. * have the option to share their genetic testing results with family members

Researchers will compare how many participants who had pre-genetic counseling with the chatbot received genetic testing to how many participants who had pre-genetic counseling with a genetic counselor received genetic testing.

What is being tested

• Genetic Information Assistant (other)
• Telegenetics with UVA genetic counselor (other)

Sponsor: University of Virginia · Participants: 96 · Started: Apr 1, 2025

Contact the study team

• Evelyn Villalobos · Phone: (434) 297-4579
• Joseph Petruzziello · Phone: (434) 323-1749

Official record on ClinicalTrials.gov — NCT06089421

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.