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tACS to Enhance Language Abilities

RecruitingHealthy volunteers welcome

Transcranial Alternating Current Stimulation (tACS) to Enhance Language Abilities

Who can join

Ages 18 to 85 · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria for Persons with Aphasia:

1. Presence of aphasia
2. Suffered a single, left hemisphere stroke
3. Stroke ≥6 months old (chronic) at the time of enrollment

Inclusion Criteria for Healthy Controls:

1. Right-handedness
2. Must be able to understand the nature of the study, and give informed consent

Exclusion criteria for Persons with Aphasia:

1. Inability to understand the nature of the study
2. Marked naming impairment
3. Impaired non-verbal, conceptual processing
4. History of significant medical or neurological disorder (other than stroke)
5. History of significant or poorly controlled psychiatric disorders
6. Current abuse of alcohol or drugs, prescription or otherwise
7. Nursing a child, pregnancy, or intent to become pregnant during the study
8. Clinically significant hearing loss
9. Contraindications to tACS
10. Contraindications to MRI

Exclusion Criteria for Healthy Controls

1. Diagnosis of a neurodegenerative disease or clinically significant cognitive complaint
2. Any unrelated neurologic or physical condition that impairs communication ability
3. History of unrelated neurological conditions including but not limited to traumatic brain injury, stroke, or small vessel disease that has resulted in a neurologic deficit
4. Any additional neurological condition that would likely reduce the safety of study participation, including central nervous system (CNS) vasculitis, intracranial tumor, intracranial aneurysm, multiple sclerosis or arteriovenous malformations
5. A medically unstable cardiopulmonary or metabolic disorder
6. Terminal illness associated with survival \<12 months
7. Major active psychiatric illness that may interfere with required study procedures or treatments as determined by the enrolling physician
8. Current abuse of alcohol or drugs, prescription or otherwise
9. Contraindications to tACS
10. Contraindications to MRI

About the study

The goal of this study is to see if transcranial alternating current stimulation (tACS) can be used to enhance language abilities in people with post-stroke aphasia. Participants will receive real and sham tACS in conjunction with various language tests. Researchers will compare the post-stroke aphasia group with aged matched controls to see if brain response to tACS differs between groups.

What is being tested

Sponsor: University of Pennsylvania · Participants: 120 · Started: Jul 12, 2024

Contact the study team

Official record on ClinicalTrials.gov — NCT06092814

Locations in the U.S.

PennsylvaniaUniversity of Pennsylvania, Philadelphia

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.