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Adipose Tissue Blood Flow in Aging Humans

Who can join

Ages 18 to 80 · All sexes · Healthy volunteers welcome

Inclusion criteria

* Within the ages of 18-35 years or 65-80 years at time of study visit
* BMI between 20-25.0 kg/m2.

Exclusion criteria:

* Presence of diagnosed cardiometabolic diseases (e.g., Type 2 diabetes, hypertension, Heart Failure)
* Taking prescription anticoagulants
* Taking prescriptions or supplements that effect adipose tissue metabolism (i.e., statins, Thiazolidinediones, niacin, atypical antipsychotics, or fish oil)
* Pregnant or nursing
* Inability to provide written informed consent
* Smokers

About the study

The goal of this basic science clinical trial is to understand whether adipose tissue blood flow changes between younger and older healthy adults.

The main question\[s\] it aims to answer are:

* Is basal and nutrient responsive adipose tissue blood flow (ATBF) different between younger and older adults * What molecular and systemic signatures related to adipose tissue blood flow are altered between these two groups.

Participants will undergo measurements of adipose tissue blood flow using the xenon washout technique, undergo 2 abdominal subcutaneous adipose tissue biopsies, and drink a sugary drink.

What is being tested

• 75 gm oral glucose load (other)

Sponsor: Mayo Clinic · Participants: 24 · Started: Feb 15, 2024

Contact the study team

Official record on ClinicalTrials.gov — NCT06096532

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.