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Endometriosis Pain
The Mechanisms Underlying Endometriosis Pain
Who can join
Ages 12 to 45 · Women
Full eligibility criteria
Inclusion criteria: * Patients with pelvic pain with and without endometriosis scheduled for an operative laparoscopic surgery for endometriosis diagnosis and/or treatment * Age 12-45 * Females Exclusion criteria: * Pregnancy * Planned hysterectomy or oophorectomy * Co-occurring vaginismus and/or vulvodynia * For patients aged 12-17 not having a parent/legal guardian willing to sign the consent and answer surveys about their child's health
About the study
Aim 1. To determine the factors contributing to pain in patients with chronic pelvic pain with and without endometriosis Aim 2. To determine the changes following endometriosis lesion removal surgery in pain and sex hormone levels.
Aim 3. To identify factors predicting clinical pain reduction after lesion removal surgery.
Additional exploratory aims might compare subgroups of patients such as patients with vs. without endometriosis, with vs. without additional chronic pain syndromes, and with vs. without hormonal treatment. In addition, the role of lesion-specific immune signatures and psychological factors on pain will be explored.
Patients with pelvic pain potentially due to endometriosis will complete questionnaires including social, health, behavioral, and psychological questionnaires. Patients will also complete a 2.5 hours study visit of psychophysical assessments of thermal and pressure stimuli. In addition, blood, urine, and saliva samples will be collected for hormonal, immune, and genetic analyses. Additional samples might be collected and stored for future analyses. For some participants, these procedures will be completed several times, including before the surgery as well as 3 months, 6 months and 1 year after surgery. After the surgery, surveys assessing pain and other symptoms will be sent every week on the first month and then monthly for 1 year. In addition, during the surgery, biopsies will be collected and analyzed to determine hormonal, immune and genetic factors.
For adolescents, a parent/legal guardian will be asked to assist in completing some of the health-related surveys (i.e., physical developmental survey, health survey, migraine history survey).
What is being tested
- Psychophysical assessment (other)
- Psychophysical assessments of experimental pain (behavioral)
- Blood, urine and saliva samples (diagnostic test)
- Biopsy and surgery-related data. (procedure)
Sponsor: Washington University School of Medicine · Participants: 120 · Started: Sep 29, 2023
Contact the study team
- Alana McMichael, MA · Phone: 314-273-6194
- Hadas Nahman-Averbuch · Phone: 314-273-6194
Official record on ClinicalTrials.gov — NCT06101303
Locations in the U.S.
| Missouri | Washington University School of Medicine, St Louis |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.