Home › Obesity › NCT06105164

Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans

Who can join

Ages 18 to 65 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Healthy individuals aged 18 to 65
* BMI of 20-35.0 kg/m2
* Normal or corrected-to-normal vision
* Good general health
* Ability to understand and willingness to sign written informed consent document

Exclusion Criteria:

* Current and/or past medical conditions
* Current and/or past eating disorder
* On a restricted diet and/or taking weight loss medication(s)
* History of bariatric surgery
* Weight fluctuation \>3% in past 3 months
* Recent history of illicit recreational drug abuse
* Current nicotine use
* Intellectual disability
* Conditions that might result in increased risks of side effects or complications from TMS or MRI

About the study

This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study satiety in healthy individuals.

TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study, the investigators will be stimulating the brain to learn more about the role of the cerebellum in satiety.

What is being tested

• Repetitive Transcranial Magnetic Stimulation (rTMS) (device)
• Sham repetitive Transcranial Magnetic Stimulation (rTMS) (device)

Sponsor: Brigham and Women's Hospital · Participants: 150 · Started: Dec 5, 2024

Contact the study team

• Laura Holsen, PhD · Phone: 617-525-8772
• Mark Halko, PhD · Phone: 617-855-2415

Official record on ClinicalTrials.gov — NCT06105164

Locations in the U.S.

Conditions

• Obesity

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.