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Biological Sex and CTEPH-related RV Dysfunction and Recovery (BIOSPHeRe)

Biological Sex and Sex Hormones Moderate Right Ventricular (RV) Dysfunction and Recovery in Chronic Thromboembolic Pulmonary Hypertension

Who can join

Ages 18 and older · All sexes

Inclusion criteria

* Adult (≥18 years old) patients diagnosed with CTEPH per current guideline standard42
* Subject must have a baseline TTE (within 3 months of diagnosis) with adequate images for RVGLS analysis
* Subject must have a right heart catheterization (RHC) at the time of diagnosis
* To be included in the Aim 2 analysis, patients must undergo PTE surgery and have a TTE performed 3-9 months after surgery with adequate images for RVGLS strain analysis

Exclusion criteria

* Unclear or mixed PH diagnosis as designated by an expert clinician at Intermountain PH center
* Any subjects \<18 years of age
* Patients diagnosed during pregnancy
* Patients without a TTE and RHC at time of diagnosis

About the study

1. To identify biological sex differences in baseline RV function in CTEPH 2. To identify biological sex differences in recovery of RV function after PTE surgery in CTEPH 3. To determine if sex hormone levels relate to RV function at CTEPH diagnosis and during recovery after PTE.

Sponsor: Intermountain Health Care, Inc. · Participants: 10 · Started: May 30, 2022

Contact the study team

Official record on ClinicalTrials.gov — NCT06105242

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.