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Outcomes and Quality of Life Following Rectal Artery Embolization for Bleeding Internal Hemorrhoids

RecruitingObservational study

Hemorrhoidal Embolization Trial-1 (HEMBO-1)

Who can join

Ages 18 to 90 · All sexes

Full eligibility criteria
Inclusion Criteria:

* Grade II or III hemorrhoidal disease as determined by a board-certified colorectal surgeon.
* Persistent or recurrent symptoms following hygiene and dietary measures or medication.
* Bleeding predominant ± pain symptoms.
* Undergoing planned rectal artery embolization (RAE) per standard clinical care.
* Male or female with age greater than 18 years, with the capacity and willingness to provide a written informed consent.
* Negative pregnancy test (if applicable).

Exclusion Criteria:

* Prior hemorrhoid surgery.
* Grade IV hemorrhoidal disease.
* Acute hemorrhoid complications.
* Chronic anal or perianal fissures.
* History of colorectal surgery or pelvic radiation.
* Inflammatory bowel disease.
* Portal hypertension or mesenteric venous congestion/occlusion.
* Inferior mesenteric artery (IMA) or internal iliac artery (IIA) stenosis or occlusion.
* Contraindication to iodinated contrast.
* Pregnant and/or breast-feeding subjects. A negative pregnancy test within 48 hours of the procedure per clinical care.

About the study

This study will assess how effective and safe rectal artery embolization works to treat symptomatic bleeding predominant internal hemorrhoids.

What is being tested

Sponsor: Mayo Clinic · Participants: 20 · Started: Jun 7, 2024

Contact the study team

Official record on ClinicalTrials.gov — NCT06106269

Locations in the U.S.

MinnesotaMayo Clinic Minnesota, Rochester

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.