Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP) Longer Term Follow Up
Assessing the Effect of Vitamin C on Infant Lung Function When Given to Pregnant Women Who Smoke - (Long Term Follow-up of a Randomized Trial)
Who can join
Ages 6 to 16 · All sexes
Full eligibility criteria
Inclusion Criteria: * Women and their offspring randomized to vitamin C versus placebo during pregnancy as well as pregnant nonsmokers and their offspring enrolled as the reference group in the original VCSIP study Exclusion Criteria: * participants who specifically withdraw consent
About the study
The overall aims of this protocol are to determine whether prenatal supplementation with vitamin C to pregnant smokers can improve pulmonary function at 10 years of age in their offspring. This is an additional continuation of the Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP) trial, to follow the offspring through 10 years of age. The hypothesis for this protocol is an extension of the VCSIP trial that supplemental vitamin C in pregnant smokers can significantly improve their children's airway function tests. The investigators aim to demonstrate sustained improvement in airway/pulmonary function and trajectory through 10 years of age.
What is being tested
- No active intervention in this protocol (previously randomized to Vitamin C) (dietary supplement)
- No active intervention in this protocol (previously randomized to Placebo) (other)
Sponsor: Oregon Health and Science University · Participants: 225 · Started: Oct 11, 2023
Contact the study team
- Cindy McEvoy, MD, MCR · Phone: 503-494-0223
- Kristin Milner, BS, CMA, CCRP · Phone: 503-494-0223
Official record on ClinicalTrials.gov — NCT06106646
Locations in the U.S.
| Indiana | Indiana University, Indianapolis |
| Oregon | Oregon Health and Science University (OHSU), Portland |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.