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Cerebellar Involvement in Cognitive Sequencing

Investigation of Cerebellar Involvement in Cognitive Sequencing

Who can join

Ages 18 to 50 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* 1\) Age 18-50;
* 2\) educational attainment of at least 8 years;
* 3\) capable of giving informed consent;
* 4\) fluent speaker of English by self-report;
* 5\) right handed.

Exclusion Criteria:

* 1\) illicit drug use within 30 days of MRI scanning;
* 2\) neurological or systemic disorder which can cause dementia or cognitive dysfunction;
* 3\) history of an Axis I psychiatric disorder including substance use disorder;
* 4\) history of definite stroke;
* 5\) focal lesion on MRI exam;
* 6\) uncorrected visual deficits by self-report
* 7\) contraindications for MRI scanning
* 8\) use of anxiolytic, antidepressant, neuroleptic, or sedative medication
* 9\) Additional exclusion criteria recommended by Wassermann for TMS neuromodulation, including: History of seizure or a family history of epilepsy, heart disease, intracardiac lines, increased intracranial pressure, history of head trauma, and history of respiratory disease

About the study

Although there is increasing recognition that the cerebellum is involved in cognition as well as motor function, the manner in which the cerebellum contributes to cognition is uncertain. One theory that might account for both motor and cognitive contributions of the cerebellum is that the cerebellum is involved in sequencing of relevant events or stimuli. Previous experiments have suggested that disruption of the cerebellum impairs the prediction of the next event in a sequence. The present experiment will examine the impact of cerebellar stimulation on brain activation during the performance of both sequence-demanding and non-sequence-demanding tasks.

What is being tested

• TMS during sequence-demanding task (procedure)
• No TMS during sequence-demanding task (procedure)
• TMS during non-sequence-demanding task (procedure)
• No TMS during non-sequence-demanding task (procedure)

Sponsor: Johns Hopkins University · Participants: 50 · Started: Mar 1, 2024

Contact the study team

• John E Desmond, Ph.D. · Phone: 410-502-3583
• JoAnna Mathena, MS · Phone: 443-571-0947

Official record on ClinicalTrials.gov — NCT06108336

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.