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Dupilumab De-escalation in Pediatric Atopic Dermatitis
RecruitingPhase 4
Dupilumab De-escalation in Pediatric Atopic Dermatitis: A Pilot Trial
Who can join
Ages 1 to 17 · All sexes
Full eligibility criteria
Inclusion Criteria: * Aged 1 to \<18 years old, either sex, any race or ethnicity * Provide signed informed consent by parent or legal guardian and informed assent if applicable * Has a physician confirmed diagnosis of atopic dermatitis * Has received dupilumab for at least 12 months for the treatment of atopic dermatitis * Has had well-controlled atopic dermatitis on dupilumab within last 6 months (defined as POEM\<=7, EASI\<=7, or IGA\<=2) * Able to speak English * Able and willing to adhere to all study procedures Exclusion Criteria: * Taking concurrent systemic medication for atopic dermatitis (e.g., methotrexate, cyclosporine, tralokinumab, abrocitinib, upadacitinib, systemic corticosteroids) * Using concurrent phototherapy for atopic dermatitis * Taking dupilumab for a clinical indication other than atopic dermatitis (such as asthma or eosinophilic esophagitis) * Poor control of atopic dermatitis * Poor control of asthma or eosinophilic esophagitis * Has used an investigational drug within 90 days or plan to use an investigational drug during the study period * Does not have health insurance or will lose health insurance during the study period
About the study
This is a pilot investigator-blinded, randomized clinical trial to assess the feasibility of dupilumab treatment discontinuation or dose-reduction in children aged 1-17 years who have achieved sustained atopic dermatitis (AD) control on dupilumab.
What is being tested
- Dupilumab - Discontinuation (drug)
- Dupilumab - Dose Reduction (drug)
- Dupilumab - Standard Dose (drug)
Sponsor: Johns Hopkins University · Participants: 30 · Started: Apr 1, 2024
Contact the study team
- Zeena Mestari, BA · Phone: +1 (848) 702-4101
- Rebecca Urbonas, BS · Phone: 813-300-1317
Official record on ClinicalTrials.gov — NCT06116526
Locations in the U.S.
| Maryland | Johns Hopkins Univerisity, Baltimore |
Conditions
From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.