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Dupilumab De-escalation in Pediatric Atopic Dermatitis

RecruitingPhase 4

Dupilumab De-escalation in Pediatric Atopic Dermatitis: A Pilot Trial

Who can join

Ages 1 to 17 · All sexes

Full eligibility criteria
Inclusion Criteria:

* Aged 1 to \<18 years old, either sex, any race or ethnicity
* Provide signed informed consent by parent or legal guardian and informed assent if applicable
* Has a physician confirmed diagnosis of atopic dermatitis
* Has received dupilumab for at least 12 months for the treatment of atopic dermatitis
* Has had well-controlled atopic dermatitis on dupilumab within last 6 months (defined as POEM\<=7, EASI\<=7, or IGA\<=2)
* Able to speak English
* Able and willing to adhere to all study procedures

Exclusion Criteria:

* Taking concurrent systemic medication for atopic dermatitis (e.g., methotrexate, cyclosporine, tralokinumab, abrocitinib, upadacitinib, systemic corticosteroids)
* Using concurrent phototherapy for atopic dermatitis
* Taking dupilumab for a clinical indication other than atopic dermatitis (such as asthma or eosinophilic esophagitis)
* Poor control of atopic dermatitis
* Poor control of asthma or eosinophilic esophagitis
* Has used an investigational drug within 90 days or plan to use an investigational drug during the study period
* Does not have health insurance or will lose health insurance during the study period

About the study

This is a pilot investigator-blinded, randomized clinical trial to assess the feasibility of dupilumab treatment discontinuation or dose-reduction in children aged 1-17 years who have achieved sustained atopic dermatitis (AD) control on dupilumab.

What is being tested

Sponsor: Johns Hopkins University · Participants: 30 · Started: Apr 1, 2024

Contact the study team

Official record on ClinicalTrials.gov — NCT06116526

Locations in the U.S.

MarylandJohns Hopkins Univerisity, Baltimore

Conditions

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.