StrokeCog-BBB to Study Cognitive Outcomes Following Stroke
Who can join
Ages 45 to 90 · All sexes
Full eligibility criteria
Inclusion Criteria: * Aged 45 years or over * One or more vascular risk factors (e.g. high blood pressure, diabetes or vascular disease such as angina, a previous heart attack, a heart bypass or peripheral artery disease in the legs) * Established vascular disease (previous MI, angina, vascular stent in the peripheral bed) * Sufficiently fluent in written and spoken English * Living independently in the community * Willing/able to give consent to study participation. Exclusion Criteria: * Current treatment with IL-1 blockade or established immune-suppressant therapy (e.g. IL-1Ra or IL-1 antibodies), or treatment within the last 3 months * Currently participating in a clinical trial of investigation medicinal product (CTIMP) or device trial. * No history of any previous ischaemic or haemorrhagic stroke, a mini-stroke or a serious brain injury * Do not have dementia * Renovascular Disease * Major neurological disease (immune mediated, previous brain tumors)
About the study
The goal of this observational study is to learn about cognitive outcomes in stroke patients. The main question it aims to answer are: 1. Is blood-brain barrier permeability compromised for years after stroke, 2. Is a blood biomarker of imbalanced angiogenesis dysregulated in chronic stroke and 3. Are there biomarkers that separately or together predicts cognitive decline after stroke, and are other MRI, blood, and clinical characteristics that are associated. Participants will undergo cognitive testing and MRIs two years apart. Researchers will compare cognitive outcomes in non-stroke patients who have cardiovascular risk factors to understand the effects of stroke on these outcomes.
What is being tested
- DCE-MRI (diagnostic test)
Sponsor: Stanford University · Participants: 350 · Started: May 17, 2022
Contact the study team
- Muhith Musabbir · Phone: 650-723-8886
Official record on ClinicalTrials.gov — NCT06116630
Locations in the U.S.
| California | Stanford University Hospital, Palo Alto |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.