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3D Printing to Improve Nasal Irrigation Outcome

3D Printing for Topical Nasal Corticosteroid Irrigations: a Randomized Clinical Trial.

Who can join

Ages 18 to 75 · All sexes

Inclusion Criteria:

* Chronic rhinosinusitis without nasal polyps (CRSsNP) or Chronic rhinosinusitis with nasal polyps (CRSwNP).

Exclusion Criteria:

* Patients with significant nasal polyps (as determined by a clinician) were excluded upfront due to the unlikeness of irrigation penetration regardless of the head position. Patients with significant atopy, cystic fibrosis, granulomatosis with polyangiitis or other connective tissue disorder, and current pregnancy were also excluded.

About the study

Three-dimensional (3D) printing has been an emerging technology with uses in a wide array of fields. This research aims to use 3D printing as a tool to provide personalized education to maximize treatment efficacy based on the patient's individual anatomy. With increased irrigation to the sinuses, we hypothesize there will be improved patient satisfaction and higher quality of life. The outcomes of this research could lead to a new option for patients who live with chronic rhinosinusitis are not candidates for surgery or are interested in less invasive options. The 3D printed nasal replica is not something that would be implanted, rather it is a hand-held device used specifically for participants to better understand their nasal anatomy.

What is being tested

• Irrigation head position (other)

Sponsor: Ohio State University · Participants: 200 · Started: Nov 1, 2021

Contact the study team

• Kai Zhao, PhD · Phone: 2673032322
• Zachary T. Root, BS · Phone: 6145609257

Official record on ClinicalTrials.gov — NCT06118554

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.