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Guided Episodic Future Thinking to Increase Physical Activity Adherence and Promote Healthy Brain Aging

Guided Episodic Future Thinking to Increase Physical Activity Adherence and Promote Healthy Brain Aging Among Mid-Life Adults: Phase II

Who can join

Ages 45 to 65 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* speak English
* have access to reliable communication (a telephone or cell phone, computer, etc.)
* normal or corrected to normal vision and hearing
* ambulatory (without the use of assistive devices)
* physically underactive
* able to give informed consent
* able to exercise continuously on the recumbent stepper exercise device for 4 minutes greater than or equal to 25 watts to demonstrate ability to perform exercise on stepper \& no aerobic exercise contraindications or other safety/physical concerns
* able to communicate with investigators, follow 2-step command \& correctly answer consent comprehension questions
* stable blood pressure and statin medication doses for 30 days as these affect vascular health/hemodynamics
* willing and able to safely enter magnetic resonance (MR) scanner and attempt the MR scan
* willing and able to attempt a blood draw

Exclusion Criteria:

* patients with arrhythmias or acute cardiac events will be excluded due to potential complications with the supervised moderate exercise
* at risk for hazard due to magnetic fields due to MR safety concerns
* have any neurologic or psychiatric disorder except depression, anxiety (including post-traumatic stress disorder)
* have history of seizures or head trauma due to MR data quality

About the study

The goal of this behavioral clinical trial is to learn how to increase physical activity in mid-life adults. Specifically, can guided imagery that includes creating mental pictures increase excitement about working out.

Participants will be asked to complete testing at the beginning of the study, following 6-weeks of an in-person exercise program, and 6-weeks after finishing the exercise program. Testing will include an exercise test, MRI, questionnaires, computer tasks, and a blood draw.

What is being tested

• Episodic Future Thinking (behavioral)
• Episodic Recent Thinking (behavioral)
• Positive Affective Imagery (behavioral)
• Neutral Affective Imagery (behavioral)
• HIIT Exercise Intervention (behavioral)

Sponsor: University of Kansas Medical Center · Participants: 160 · Started: Feb 23, 2024

Contact the study team

• Morgan Brucks · Phone: (913) 588-0173

Official record on ClinicalTrials.gov — NCT06123182

Locations in the U.S.

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.