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Controlling Locomotion Over Continuously Varying Activities for Agile Powered Prosthetic Legs

RecruitingHealthy volunteers welcome

Who can join

Ages 18 to 65 · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion criteria for able-bodied participants will be:

* Aged between 18 to 65 years

Exclusion criteria for able-bodied, young adult participants will be:

* Pregnant (self-report)
* Any significant neuromuscular or musculoskeletal disorder that would interfere with the study
* Unable to walk for 20 minutes
* History of any cardiovascular, vestibular, or visual diseases and/or impairments that may interfere with the study
* Cognitive deficits that would impair their ability to give informed consent or impair their ability to follow simple instructions during the experiments. In the case of screening for cognitive deficits, the consenting researcher will ask the subject if he/she has any prior history of cognitive deficits.
* Adults with a known allergy to medical grade tape

Inclusion criteria for subjects with amputation will be:

* Aged between 18 to 70 years.
* Weigh less than 250 lbs due to limitations in the design of the prosthesis.
* Amputee subjects will be more than two months post independent ambulation with an amputation at the transfemoral level in order to use the above-knee prosthesis.
* Amputee subjects will have a mobility classification of K2/K3/K4 ambulators (minimum community ambulatory) and have the ability to ambulate without an assistive device beyond their prosthesis.

Exclusion criteria for subjects with amputation will be:

* Weigh over 250 pounds body
* Pregnant (self-report)
* Any significant neuromuscular or musculoskeletal disorder that would interfere with the study
* Inactive or physically unfit, unable to walk for 20 minutes
* An excessively long residual limb length, and/or a non-removable cosmetic cover determined by the prosthetist performing the evaluations
* Cognitive deficits or visual impairment that would impair their ability to give informed consent or impair their ability to follow simple instructions during the experiments. In the case of screening for cognitive deficits, the consenting researcher will ask the subject if he/she has any prior history of cognitive deficits.
* Co-morbidity that interferes with the study (e.g., pace maker placement, severe ischemia, cardiac disease, etc.)
* Adults unable to consent
* Adults with a known allergy to medical grade tape

About the study

The overall goal of this project is to model human joint biomechanics over continuously-varying locomotion to enable adaptive control of powered above-knee prostheses. The central hypothesis of this project is that variable joint impedance can be parameterized by a continuous model based on measurable quantities called phase and task variables. This project will use machine learning to identify variable impedance functions from able-bodied data including joint perturbation responses across the phase/task space to bias the solution toward biological values.

What is being tested

Sponsor: University of Michigan · Participants: 40 · Started: Dec 6, 2023

Contact the study team

Official record on ClinicalTrials.gov — NCT06138977

Locations in the U.S.

MichiganRehab Lab, University of Michigan, Ann Arbor

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.