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Effect of Ketamine on Intraoperative Motor Evoked Potentials

RecruitingPhase 3

Who can join

Ages 18 to 100 · All sexes

Full eligibility criteria
Inclusion Criteria:

* Adult patients (\>18 years of age) undergoing posterior spinal fusions.

Exclusion Criteria:

* Sensitivity or allergy to ketamine.
* Schizophrenia or other psychotic conditions
* Uncontrolled hypertension with systolic blood pressure greater than 180 mmHg
* Myocardial Infarction
* Large vascular aneurysms
* Patients on ketamine as outpatient therapy.

About the study

The goal of this clinical trial is to learn about the effect of ketamine on intraoperative motor evoked potentials in adult patients undergoing thoracolumbar spinal fusions. Participants will undergo a standard anesthetic. In addition to the standard anesthetic, the patients will be administered increasing doses of ketamine with motor-evoked potentials being measured at each dose, to assess any impacts.

What is being tested

Sponsor: University of California, San Francisco · Participants: 20 · Started: Dec 1, 2023

Contact the study team

Official record on ClinicalTrials.gov — NCT06140927

Locations in the U.S.

CaliforniaUniversity of California, San Francisco, San Francisco

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.