Home › Mycobacterial Infections › NCT06155747
Transmission and Acquisition of Nontuberculous Mycobacteria Outbreak Investigation (TrANsMIt)
Who can join
1 Month – 99 Years · All sexes
Full eligibility criteria
Inclusion Criteria: * Male or female participant of any age who has a history of NTM or a first positive NTM culture collected as part of routine clinical care from expectorated sputum, induced sputum and/or bronchoalveolar lavage. Exclusion Criteria: * No NTM respiratory culture
About the study
The goal of this observational study is to support U.S. healthcare centers in determining if they may have an NTM outbreak among patients receiving care at the healthcare center. The study applies a standardized, reproducible outbreak investigation approach across diverse healthcare settings. This study focuses on patients with NTM isolates suspected to be part of an outbreak, receiving care at a specific U.S. healthcare center.
The main questions it aims to answer are:
Can application of a standardized epidemiologic investigation framework support evaluation of whether clustered NTM infections may be consistent with healthcare-associated exposure? Are respiratory NTM isolates genetically related to environmental NTM isolates identified within healthcare settings or shared home water sources?
Researchers will compare clinical, epidemiologic, molecular, and infection prevention data from suspected NTM isolates to determine whether patterns are consistent with healthcare-associated transmission or acquisition.
Participants (healthcare centers and selected patients) will:
* Implement a standardized epidemiologic investigation using the Healthcare-Associated Links in Transmission of Nontuberculous Mycobacteria (HALT-NTM) toolkit * Submit available respiratory and environmental NTM isolates for molecular comparison, when applicable * Optionally collect dust and water biofilm samples within the healthcare setting * Complete a survey to provide home address history for watershed mapping, when clustered infections are identified
What is being tested
- Epidemiologic investigation (other)
Sponsor: University of North Carolina, Chapel Hill · Participants: 100 · Started: Mar 1, 2023
Contact the study team
- Principal Investigator · Phone: 919-445-4240
Official record on ClinicalTrials.gov — NCT06155747
Locations in the U.S.
| North Carolina | University of North Carolina- Chapel Hill, Chapel Hill |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.