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EUS-guided Celiac Plexus Block vs. Sham in Chronic Pancreatitis

Randomized Trial of EUS-guided Celiac Plexus Block vs. Sham for Palliation of Pain in Chronic Pancreatitis

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Age ≥ 18 years
* Abdominal pain of at least 3 months duration and a VAS score ≥ 3, with or without the use of narcotic analgesics.
* Diagnosis of chronic pancreatitis on EUS examination, with ≥ 5 features on EUS.
* No other cause of abdominal pain

Exclusion Criteria:

* Age \< 18 years.
* History of prior EUS-CPB.
* Use of anticoagulants that cannot be discontinued for the procedure.
* Clinically significant allergy to bupivacaine or triamcinolone.
* Unable to obtain consent for the procedure from either the patient or LAR.
* Intrauterine pregnancy.

About the study

The aim of this randomized trial is to assess the efficacy of EUS-CPB in the alleviation of abdominal pain in patients with chronic pancreatitis.

What is being tested

• EUS-guided celiac plexus block (procedure)
• Sham procedure (procedure)

Sponsor: Orlando Health, Inc. · Participants: 94 · Started: Dec 7, 2023

Contact the study team

• Charles Melbern Wilcox, MD · Phone: 321-841-2431
• Barbara J Broome · Phone: 321-841-7031

Official record on ClinicalTrials.gov — NCT06178315

Locations in the U.S.

Conditions

• Chronic Pancreatitis

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.